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A Novel Synthesis of 3,5-disubstituted Δ2-isoxazoline as a Precursor to Various Diabetic Medications

Charlie Wang

Over a 6 week period during the summer of 2018, I conducted research upon the novel synthesis of 3,5-disubstituted Δ2-isoxazoline as a precursor to various diabetic medications.

After 6 weeks, we did succesfully synthesize the 3,5-disubstituted Δ2-isoxazoline using Lead (II) Acetate in the final cyclization reactions. This was a novel method in this particular synthesis and carries many unique benefits with it. The Lead (II) Acetate is significantly cheaper than the other metals that we tested in our synthesis of 3,5-disubstituted Δ2-isoxazoline. These metals include Nickel (II) Chloride and Palladium (II) Chloride. 

3,5-disubstituted Δ2-isoxazoline  is a precursor to many known Diabetic medications which are known as glucose-derived spiro-isoxazolines and ISO-1. The successful synthesis of 3,5-disubstituted Δ2-isoxazoline could make both of these medications much more affordable. Additionally, this could lead to the widespread distribution of these medications around the globe which would allow people from across the world to access affordable Diabetes treatment. This would give people new opportunities to live healthy lives. 

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